This webinar will provide you with some insights on several functional assays for SARS-CoV-2, suitable for high throughput screening (HTS) applications, for the identification of novel antiviral drugs. The assay platform that will be described includes a cell-based viral entry assay, useful for the identification of inhibitors of the viral entry step, as well as biochemical assays, which provide an important tool to screen for inhibitors of SARS-CoV-2 life cycle at different stages. Overall, this comprehensive assay platform could be of great value for the identification of novel drugs active against viral as well as host cell targets, and that could act synergically to prevent viral infection at multiple stages.
Keywords:
SARS-CoV-2, COVID-19, antiviral drugs, viral entry assay, biochemical assay, ACE2-spike interaction, MPro (3CLpro)
Speakers:
