ACTIVE PROJECTS
Innovation Fund Denmark (IFD) – Grand Solutions 2018
Title: HB-086 – HB-086 (hMeteorin), an innovative biopharmaceutical development candidate for neuropathic pain
Start: September 2018
European Commission – Horizon 2020-Innovative Medicines Initiative 2 (IMI2):
Title: ReSolute – Research empowerment on solute carriers
Start: July 2018
Italian Ministry of Research (MIUR) – PON 2014-2020
Title: PerMedNet – Personalized Medicine for Innovative Strategies in Neuropsychiatric and vascular diseases
Start: May 2018
European Commission – Italian Ministry of Research (MIUR) – Horizon 2020- Eurostars 2
Title: Chem2Bio – A novel structure based discovery platform to translate orphan GPCR into new drug targets
Start: November 2017
Ministry of Economic Development – FCS – Research & Development Big Projects – PON
Title: Q-RARE – Integrated technological platform for the identification and development of new drugs for the treatment of rare diseases or high dissatisfied need of care
Start: November 2017
European Commission – Horizon 2020-Innovative Medicines Initiative 2 (IMI2)
Title: NGN-PET – Modelling Neuron-Glia Networks into a drug discovery platform for Pain Efficacious Treatments
Start: April 2017
Lombardy Region – POR FESR 2014-2020
Title: iPSLight – New iPSC biotechnological systems for pharmaceutical development in the field of neurodegenerative diseases
Start: February 2017
Italian Ministry of Economic Development (MISE) – EuroTransBio
Title: NeurOptics – Development of iPSCs derived Opto-neurons suitable for high-throughput screening (HTS)
Start: January 2017
Ministry of Economic Development – FCS H2020 PON
Title: FARMIDIAB – Metabolic disorders with high and dissatisfied need of care and their complications: Research and development of new pharmacological approaches and innovative targets
Start: January 2017
Lombardy Region – POR FESR 2014-2020
Title: COGNIPLANT – New botanical products for the prevention of cognitive deficits in the adult age and aging phase
Start: December 2016
European Commission – Horizon 2020-Innovative Medicines Initiative 2 (IMI2)
Title: PHAGO – Inflammation and AD: modulating microglia function – focussing on TREM2 and CD33
Start: November 2016
INSIGHTS ON SPECIFIC GRANT PROJECTS
COGNIPLANT - New botanical products for the prevention of cognitive deficits in the adult age and aging phase
Cognitive decline is a widespread problem both in healthy elderly and those suffering from diseases. Some recent studies have shown that polyphenols and natural terpenes have neuroprotectional activities. The project intends to verify this aspect, evaluating between the standardized extract of Curcuma long L. (curcuma), of Centella asiatica L. or their combination the most suitable candidate. The Phytosome® technology will allow to convey a greater concentration of active principle on the central nervous system (CNS) and to express its neuroprotection function in the brain areas involved. In vitro tests conducted through a platform consisting of recombinant cell lines for molecular targets belonging to different classes as well as in vivo tests in the rat and subsequently on the healthy volunteer will allow the validation of the biological effect.
The Consortium is represented by three Italian industrial companies located in Lombardy Region (Indena S.p.A., Axxam S.p.A., GricarChemical s.r.l.) and the University of Milan – DiSFeB. The collaboration between the academic world and the industry will allow to reach new products with specific scientifically and industrially validated action, applicable in the nutraceutical sector, consequently bringing competitiveness to the sector, to the partners, to the territory and benefits in terms of wellbeing and containment of public costs for the treatment of cognitive decline in the elderly.
Il declino cognitivo rappresenta un problema largamente diffuso sia in soggetti sani che affetti da patologie. Alcuni recenti studi hanno evidenziato che polifenoli e terpeni naturali hanno attività neuroprotettrici. Il progetto intende verificare questo aspetto, valutando tra l’estratto standardizzato di Curcuma long L. (curcuma), di Centella asiatica L. o loro combinazione il candidato più idoneo. La tecnologia Phytosome® permetterà di veicolare una maggior concentrazione di principio attivo sul SNC ed esplicarvi la propria funzione neuroprotettrice nelle aree cerebrali interessate. Prove in vitro condotte attraverso una piattaforma costituita da linee cellulari ricombinanti per target molecolari appartenenti a differenti classi nonché prove in vivo nel ratto e successivamente sul volontario sano consentiranno la verifica dell’effetto biologico.
Il progetto vede in prima linea un partenariato composto da tre imprese industriali lombarde (Indena S.p.A., Axxam S.p.A., GricarChemical s.r.l.) e dall’Università di Milano – DiSFeB. La collaborazione tra il mondo accademico e l’impresa permetterà di pervenire a nuovi prodotti ad azione specifica scientificamente ed industrialmente validati, applicabili nel settore nutraceutico, portando conseguentemente competitività al settore, ai partner, al territorio e benefici sotto il profilo del benessere della persona e del contenimento dei costi pubblici per la cura del declino cognitivo nel soggetto anziano.
COMPLETED PROJECTS
Alzheimer’s Drug Discovery Foundation (ADDF)
Title: Exploratory Optimization of New CX3CR1 modulators for the treatment of AD
Start: September 2017- August 2018
Italian Ministry of Economic Development (MISE) – EuroTransBio
Title: OPTEL – A novel optogenetic electrophysiology platform for ion channel and transporter screening
Term: December 2015 – November 2017
Italian Ministry of Research (MIUR) – National Technological Cluster Life Sciences (ALISEI)
Title: Cutting-edge technologies to increase safety and efficacy of drugs and vaccines (MEDINTECH)
Term: January 2014 – December 2016
European Commission – Seventh Framework Program
Title: Satiety Innovation (SATIN – www.satin-satiety.eu)
Term: January 2012 – December 2016
SATIN poster available on demand
EUREKA – Italian Ministry of Research (MIUR), Eurostars Programme – X Call
Title: Novel therapeutic approaches to combat obesity pandemic and its sequel (Hypo greedy)
Term: September 2013 – August 2016
Alzheimer’s Drug Discovery Foundation (ADDF)
Title: Optimization of P2X7 antagonists for AD treatment
Term: December 2015 – July 2016
European Commission – Seventh Framework Program
Title: From sea-bed to test-bed: harvesting the potential of marine biodiversity for industrial biotechnology (SeaBioTech)
Term: August 2012 – July 2016
EUREKA – Italian Ministry of Research (MIUR), Eurostars Programme – VIII Call
Title: Novel therapeutic approaches for resolution of inflammation (ChemExit)
Term: December 2012 – May 2016
Campania Region – POR – FESR
Title: TIMING – Innovative Therapies of chronic inflammatory, metabolic, neoplastic and geriatric diseases
Term: August 2013 – December 2015
Campania Region – POR – FESR
Title: OCKey – Oncology and Cardiology Key Targets
Term: August 2013 – December 2015
Italian Ministry of Research (MIUR) – PON Program
Title: An integrated technological platform for the development of new drugs for rare diseases (PON1_00862)
Term: July 2011 – December 2015
Lombardy Region and Italian Ministry of Research (MIUR)
Title: OMICS (Optical Method for Ion Channel Screening)
Term: December 2011 – March 2015
EUREKA – Italian Ministry of Research (MIUR), Eurostars Programme – V Call
Title: Innovative GLP-1R modulators for Type-2 Diabetes treatment (InsuSecret)
Term: July 2011 – December 2014
Ministry of Economic Development – EuroTransBio
Title: NeuroSafe – Neurotoxicity Safety Platform
Term: November 2012 – October 2014
Lombardy Region – FRIM – FESR 2011
Title: Cardiac Safety Panel (CaSP)
Term: February 2013 – July 2014
Lombardy Region – FRIM 2011
Title: Systems for Quality Control and automated management of chemical libraries for HTS
Term: February 2013 – July 2013
Fast Forward LLC and MERCK KGaA
Title: Chloride Channel blockers discovery program for inflammatory microglia suppression (CLIC1)
Term: January 2012 – December 2012
Lombardy Region – ATP 2009
Title: Identification of GOAT inhibitors (SLIMGOAT)
Term: June 2010 – December 2012
Fast Forward & MERCK KGaA
Title: Small Molecule NCX1 blockers for axonal survival in Multiple Sclerosis
Term: May 2011 – October 2012
Fast Forward LLC and Juvenile Diabetes Research Foundation (JDRF)
Title: Discovery research of innovative immunosuppressant for prevention of type 1 diabetes
Term: June 2011 – July 2012
Alzheimer’s Drug Discovery Foundation (ADDF)
Title: Small Molecule P2X7 Antagonists for AD treatment
Term: May 2011 – April 2012
Lombardy Region – Proceeded Innovation and Services Organization
Title: Frozen cells in HTS (Forzen4Array)
Term: November 2010 – April 2012
EUREKA – Italian Ministry of Research (MIUR), Eurostars Programme – III Call
Title: Identification of ICRAC antagonists (ICRAC)
Term: June 2010 – May 2012
European Commission – Seventh Framework Program
Title: Neuron – glia interactions in health and disease (NGIDD)
Term: April 2008 – March 2012
European Commission – Sixth Framework Program
Title: Production of innovative biomedical drugs (CONCO)
Term: February 2007 – January 2012
Lombardy Region – GrantMetadistretti 2008
Title: From the molecular target to therapy: a drug discovery integrated process for innovative pain treatments (NaVs for Pain)
Term: November 2008 – November 2011
Italian Ministry of Foreign Affairs (MAE), Italian Ministry of Research (MIUR) and Korean Ministry of Education, Science and Technology (MEST) Law 401/90 – Bilateral projects
Title: Bioactive compounds for the valorization and promotion of traditional food
Term: January 2010 – December 2010
Fast Forward LLC and Juvenile Diabetes Research Foundation (JDRF) – Sponsored Research Agreement
Title: Identification of Kv1.3 blockers for treatment of Type1 diabetes and Multiple Sclerosis
Term: July 2009 – December 2010
European Commission – Sixth Framework Program
Title: Development of clinical diagnostic tools in atherosclerosis (SOUTH)
Term: October 2006 – March 2010
Italian Ministry of Research (MIUR) and Region of Lombardy Law 593/2000 art.12
Title: Identification and characterization of GPCRs (G protein – coupled receptors) inhibitors
Term: March 2006 – December 2009
European Commission – Sixth Framework Program
Title: Targeting Cell Migration In Chronic Inflammation (MAIN)
Term: September 2007 – December 2008
Lombardy Region – Metadistretti 2005
Title: Identification and characterization of chemokine receptors
Term: July 2006 – December 2008
Italian Ministry of Research (MIUR) and Sardinia Region – Law 593/2000 art.13 (Lab. 5)
Title: Development of methodologies for the modeling and the study of biodrugs
Term: January 2006 – December 2008
Italian Ministry of Productive Activities (MAP) – Law 1982/46 – Lombardy FIT
Title: Novel targets identification
Term: September 2004 – August 2008
Italian Ministry of Research (MIUR) – Law 593/2000 art.10
Title: Drug discovery technologies
Term: September 2003 – August 2007
Lombardy Region – Metadistretti 2003
Title: Application of mouse embryonic stem cells in HTS
Term: January 2005 – July 2007