Electrophysiology

Electrophysiology unit

Axxam has more than 13 years experience in working with electrogenic proteins and a deep understanding of ion channel biology. Our Electrophysiology Unit offers detailed analysis of  compounds applying different experimental settings to elaborate on the compounds’ modes of action. Axxam offers both manual and automated patch-clamp facilities.
On the HEKA-based manual patch-clamp setup, a variety of protocols is available for both ligand and voltage-gated ion channels, as well as for transporters and exchangers. The platform is used during the assay development to validate our cell lines and for analyzing the pharmacological and biophysical behavior of testing compounds, along with profiling programs.

TheQPatch 16X-based automated Patch Clamp unit allows:

  • More than 300 data points per day
  • Medium throughput screening for hit discovery, hit confirmation and cardiac safety
  • Compound profiling on ready-to-use Axxam assays or on adapted client assays

Axxam has already validated several assays that can immediately been used for services and additional assays can be adapt upon Client’s request.

Download the QPatch Validated Cell-Based Assays List and contact us for additional information