AXXAM

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Webinar

Breaking the ICE: Automated and Interactional Ion Channel Data Analysis

Webinar on demand

About the Webinar:

Automated patch clamp and calcium oscillation assays empower researchers to measure ion channel activity at scale, providing critical insights into drug targets and toxicity. However, the sheer volume of data generated by these complex assays can create a significant bottleneck in data analysis, often taking hours or even days to resolve.
Genedata Screener® with its Ion Channel Extension (ICE) solves this problem. It seamlessly integrates with the most common ion channel instrumentation and IT environments and offers ready-to-go analysis workflows tailored for typical assay formats, ensuring efficient data processing. This automates hours or days of analysis in minutes.
In our upcoming webinar, we’ll delve into how Axxam leverages Screener ICE for data analysis across their extensive portfolio of medium and high-throughput ion channel assays. We explore how Screener ICE is used in their implementation of Screener to support scalable and automated data analysis while maintaining the necessary interactivity, integration, and results visualization for robust assay quality control and review. Ultimately, discover how it facilitates the selection and characterization of ion channel modulators.

Keywords: Axxam, Genedata, Screener, ion channels, electrophysiology, high-throughput, data analysis, Automated Patch Clamp (APC), calcium oscillation, Nanion, Sophion, data workflows, data quality control, ion channel modulators, webinar

Speakers:

  • Jean-François Rolland, Director of Biological Sciences, Axxam, Milan, Italy

  • Samuel Bradberry, Principal Scientist, Data Analysis, Axxam, Milan, Italy

  • Guillaume Lemercier, Project Manager, Genedata Screener, Basel, Switzerland

Jean-François Rolland is the Director of the Biological Sciences Department at Axxam. He is an electrophysiologist by background and has been “playing” with ion channels for more than 20 years, first in academia and since 2007 in the biotech world. After his PhD in Brussels and a post-doc in Italy he worked for four years at Xention, a Cambridge (UK)-based ion channel company. At the end of 2011, he joined Axxam, where he established the laboratory of Automated Patch-clamp and spent more than 10 years exploring new targets and establishing and validating new assays.
Since the beginning of 2023, he is Director of the Biological Sciences Department, heading several groups of highly skilled scientists, who generate in-vitro assays using state-of-the-art innovative biology capabilities by means of multidisciplinary and integrated approaches. In particular, Axxam are pioneers in using in-vitro optogenetics and offers unique reliable assays for automated organellar electrophysiology.

Samuel (Sam) Bradberry is a Principal Scientist in the Data Analysis group at Axxam in Milan, Italy. He is dedicated to the support of data analysis in HTS campaigns for Axxam’s clients and the development of internal data analysis infrastructure, including in-house implementations and integrations with Genedata Screener. He holds a PhD and master’s degree in physical organic chemistry having focussed on luminescent probes and measurement of supramolecular systems, from which he has specialized in the management, processing, and interpretation of experimental scientific data.

 After his PhD in biochemistry, Guillaume Lemercier did a first postdoctoral position at the EPFL in Lausanne at the interface of chemistry and biology, followed by another postdoctoral opportunity in the High-Throughput Screening group at Merck Serono Geneva where he developed biological assays and performed HT screens targeting malarial proteins. In 2008, he joined a biotech company in the Basle area as a laboratory head and screening head, where he spent more than 10 years developing assays, running screens and characterizing promising hits using a wide range of technologies. These efforts spanned various internal and collaborative projects with pharmas. With his strong background in biological assays, Guillaume joined Genedata in 2019, and is now Project Manager for the Screener Platform since 2020.

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