Compound Management Services
Axxam delivers end-to-end compound management services designed to support high-throughput screening (HTS) and hit-to-lead programs with precision, traceability, and scalability. Our integrated infrastructure combines secure, high‑performance storage, automated liquid handling, and HTS‑ready provisioning to keep screening programs on track.
Your compounds, treated as strategic assets
We protect quality, integrity, and traceability across every vial and plate – so your data, decisions, and programs remain reliable
Speed and flexibility,
built in
From rapid confirmation to large-scale screening, we adapt formats, volumes, and layouts to your assays without compromising timelines
Precision
you can trust
Advanced automation, acoustic and tip‑based transfers, and per‑well verification deliver assay‑ready plates with full audit confidence
End-to-end
lifecycle control
Integrated storage, handling, recovery, and global logistics preserve compound integrity and maximize long‑term collection value
A partner that keeps science moving
Fast, responsive, and quality‑driven, we deliver tailored solutions aligned with what your team needs, when and how they need it
From storage to dispensing, every step is standardized, controlled, and fully traceable, enabling rapid turnaround and reliable logistics. Embedded within Axxam’s discovery workflows, our capabilities ensure that libraries and samples are accurately processed, readily accessible, and seamlessly deployed, accelerating decision‑making and progress toward validated drug candidates.
Storage
Sample handling
Logistics & shipments
Quality control
Integrated platform
The same rigorous quality standards apply to Axxam’s proprietary libraries and client‑owned collections, ensuring consistent performance across every campaign.
STORAGE
Compound integrity starts with the right storage strategy
Axxam’s state‑of‑the‑art storage infrastructure is designed to protect sample quality, ensure full traceability, and keep discovery programs moving without interruption.
Automated, temperature‑ and humidity‑controlled systems support both vials and plates, minimizing degradation, evaporation, and freeze–thaw stress while enabling fast, reliable access. Complementary cold and ultra‑low temperature storage (+4 °C, −20 °C, −80 °C), together with nitrogen‑inert room‑temperature environments, protects sensitive and acoustic‑compatible formats, preserving concentration, solubility, and usability.
Centralized, barcode‑based tracking enables rapid selection, retrieval, and export. Redundant power, active monitoring, and a 24/7 response framework ensure continuity, turning potential downtime into a controlled, fully documented event.
SAMPLE HANDLING
Reliable screening starts with accurate sample handling
Axxam executes compound reformatting, mother‑plate replication, cherry‑picking, and dose‑response preparation daily through standardized, high‑throughput workflows designed for speed, flexibility, and reproducibility.
Parallelized and customizable operations enable rapid turnaround from sample receipt to assay‑ready plates, supporting both focused follow‑up studies and large screening campaigns. Industry‑leading tip‑based and acoustic liquid‑handling platforms ensure precise, reliable transfers across volumes from nanoliters to milliliters, with full audit trails capturing every step for confident decision‑making.
LOGISTICS & SHIPMENTS
Axxam manages end‑to‑end compound logistics, ensuring that materials move securely, compliantly, and on time across the discovery lifecycle. From order intake and labeling to validated packaging, courier coordination, and customs support, every shipment is controlled and fully traceable.
Standardized import workflows ensure incoming materials are verified, registered, barcoded, and assigned to the appropriate controlled storage conditions. Outgoing shipments use validated, temperature‑controlled pack‑outs (RT, 2–8 °C, −20 °C, −80 °C, dry ice), supported by full documentation and chain‑of‑custody tracking through to proof of delivery, ensuring uninterrupted screening timelines.
QUALITY CONTROL AND COMPOUND RECOVERY
Confidence in screening starts with robust quality control
Structured QC protocols verify sample integrity, volume and concentration, solvent composition, and plate layout before release. Automated checks against defined acceptance criteria generate clear, audit‑ready reports that support reliable downstream experiments.
To further protect program continuity, Axxam offers compound recovery solutions that stabilize moisture‑affected or compromised samples. Nitrogen‑inert environments minimize oxygen and humidity exposure, restoring usability – including acoustic source plates – while preserving concentration and activity. Together, QC and recovery safeguard compound value and reduce waste.
COMPOUND MANAGEMENT INTEGRATED PLATFORM
Axxam delivers a secure management platform that connects instruments, inventory, and data across the full compound lifecycle, ensuring real‑time traceability, faster turnaround, and fewer errors.
All compounds are registered, tracked, and managed within Axxam’s internal systems, providing full auditability, reporting, and documentation independent of any external platform.
For clients who want direct, real‑time access to their collections and data, Axxam offers optional integration with CDD Vault. When enabled, selected inventory, compound, and assay data are mirrored into a client‑specific CDD Vault workspace, creating a single environment for chemistry, biology, inventory, documentation, and data visualization. Whether using CDD Vault or relying on Axxam’s native workflows, clients benefit from the same level of control, transparency, and data quality.
FAQ
How does a CRO ensure compound quality, traceability, and integrity throughout the workflow?
A CRO ensures compound quality and integrity by combining controlled storage conditions, standardized registration processes, barcode based tracking, and routine quality assessments. Automated handling systems reduce manual interventions, while digital inventory platforms provide end-to-end traceability from initial receipt to final utilization. Additionally, Axxam’s proprietary Laboratory Information Management System (LIMS) enables fully customized data exports tailored to each client’s specific needs, ensuring seamless integration with internal workflows and maximizing operational transparency. This integrated approach supports reliable, consistent compound management across all project stages.
How can a CRO scale compound management from small collections to large, high throughput libraries to support client needs?
Scalability is achieved through automated storage systems, flexible liquid handling platforms, and efficient processes for plating, reformatting, and data handling. CROs like Axxam employ modular workflows that can expand as project needs grow, allowing both small bespoke libraries and large, multi program collections to be managed with the same level of efficiency and consistency.
What plate formats, volumes, and logistics services can a CRO typically provide?
Most CROs offer a wide range of plate formats (commonly 96-, 384- and 1536-well), various dispensing volumes thanks to the combination of tip-based and acoustic-based technologies, and services such as reformatting, cherry picking, dose response plate generation, and the preparation of assay ready plates. In addition, they usually support both internal routing to screening units and external shipment to partners, enabling seamless integration into a broader research workflow.