Hit & Lead Discovery
Compound Management Services
Support high-throughput screening through integrated compound storage, handling, and assay-ready sample management.
Hit Identification
Identify qualified hits through high-throughput and virtual screening with robust assays and curated libraries.
Screening Platforms
Hit-to-Lead
Optimize screening hits into high-quality lead compounds through integrated medicinal chemistry, biology, and ADME-driven drug discovery workflows.
Exploratory Toxicology
Assess compound safety and potential liabilities through integrated exploratory toxicology assays and tissue-relevant cellular models.
Hit and lead discovery are critical stages in the progression from target biology to high-quality chemical starting points for medicinal chemistry. At Axxam, we integrate experimental high-throughput screening (HTS) with virtual screening strategies to efficiently identify high-quality hit compounds.
Clients benefit from integrated compound management services, including secure storage, sample handling and preparation, and logistics for screening campaigns. This ensures traceability, consistency, and reliability throughout the screening process and supports efficient progression from hit identification to downstream optimization.
Our approach integrates multidisciplinary expertise in biology, chemistry, engineering, and data analysis to ensure assay performance, data quality, and decision making are aligned from the outset.
By combining sensitive and robust assays with advanced screening technologies and in silico selection, we maximize the probability of identifying biologically relevant and chemically tractable hit compounds.
Hit selection is followed by structured hit-to-lead campaigns, supported by iterative testing, SAR development, and profiling in secondary and orthogonal assays. This integrated workflow improves compound quality, accelerates lead generation, and contributes to the overall de-risking of discovery programs.