Your channel, our solution

Are you working with electrogenic proteins expressed on plasma or organellar membranes? Do you need support studying ion channel, transporter or exchanger biology? Our team of skilled electrophysiologists have at their disposal an eclectic panel of both manual and automated patch-clamp devices allowing them to define the best strategy to assist your request.

During the assay development phase, our platforms allow us to pharmacologically and biophysically validate “in house
generated” or transferred cell lines. Then, using the most suitable tools, we design fine-tuned experimental conditions to perform small and medium-scale compound testing and primary screenings, as well as hit validation experiments and mode of action studies on ligand- and voltage-gated ion channels using the proper configuration (cell attached, whole-cell, inside-out or outside-out).

Discover our patch clamp platforms

  • Whole cell or single channel (inside- and outside-out configurations) recordings
  • Cellular and organellar electrophysiology
  • Low throughput compound profiling & mode-of-action studies
  • Optogenetics
  • iPSC-derived cell electrophysiology (temperature control)
  • Fast internal (Port-a-Patch) and external solution exchange
  • Medium-high throughput screening for hit discovery, hit confirmation and SAR campaign
  • On off-the-shelf assays or adapted clients’ assays
  • Preliminary cardiac safety profiling
  • Suitable for iPSC-derived cell electrophysiology
  • Current clamp and temperature control available
  • Implemented for Genedata analysis settings
  • Fully automated high throughput screening for hit discovery, hit confirmation and SAR campaign
  • On tailored-made assays or adapted clients’ assays
  • Suitable for clone selection during cell line generation
  • Fast internal solution exchange
  • iPSC-derived cell electrophysiology
  • Current clamp and temperature control available
  • Optogenetics (opto-SyncroPatch)
  • Implemented for Genedata analysis settings
  • Automated LysoPatch (worldwide premiere)

Off-the-shelf assays

Axxam has already validated several assays that can immediately been used for services and additional assays can be adapt upon client’s request. 

Interested in going deeper into the cell?

In the last few years, we have developed a huge expertise on organellar electrophysiology enabling the study of ion channels localized on the membrane of nuclei (manual NucleoPatch), lysosomes (LysoPatch and automated LysoPatch) and mitochondria (manual MitoPatch).

Related Content

Please find below a selection of our scientific publications and posters:

Voltage-gated ion channels

Parallel all-optical assay to study use-dependent functioning of voltage-gated ion channels in a miniaturized format (SLAS Discov. 2021 Mar;26(3):460-469. doi: 10.1177/2472555220976083)

Ligand-gated ion channels

A new electro-optical approach for conductance measurement: an assay for the study of drugs acting on ligand-gated ion channels (Sci Rep. 2017 Mar 21:7:44843. doi: 10.1038/srep44843)

Solute carriers

An overview of cell-based assay platforms for the solute carrier family of transporters (Front Pharmacol. 2021 Aug 10:12:722889. doi: 10.3389/fphar.2021.722889. eCollection 2021)


Identifying ryanodine receptor modulators: from high-throughput screening to single channel recording (download poster)

Potassium channel

A potassium channel agonist protects hearing function and promotes outer hair cell survival in a mouse model for age-related hearing loss (Cell Death Dis. 2022 Jul 11;13(7):595. doi: 10.1038/s41419-022-04915-5)

Scroll to Top