AXXAM

  1. Integrated Drug Discovery >

Our model and partners

The road from target identification to the development of a new drug treatment might be a long and bumpy ride if not tackled sharing efforts and skills among experts. We strongly collaborate with our client’s scientists forming a unique team and sharing with them our deep expertise in assay development, High-Throughput Screening and profiling/Hit-to-Lead activities, but also rely on strong partners to enlarge the service offering covering many of the steps needed to advance a hit identification project started at Axxam throughout the drug discovery process and part of the drug development process.

We have established a consortium of centres of excellence with specific drug discovery platforms to offer best-in-class fully integrated drug discovery services, that can be integrated with client’s preferred service providers.

While immortalized cell lines might be the choice of election for High-Throughput Screening increasing the chance of finding good hits testing hundreds of thousands of molecules in a time and cost effective manner, using a more relevant and physiological environment such as primary cells or induced Pluripotent Stem Cells (iPSCs) offers a deep understanding of the biological mechanisms under investigation. Our preferred source of iPSCs is FUJIFILM Cellular Dynamics, Inc. (FCDI), with whom we have a long-standing collaboration.
When it comes to rodent primary cells and disease models, we rely on NeuroZone, an Italian company located in our campus that guarantees the access to fresh material

Symeres, a leading European contract research organization, is our preferred partners to work with to support the Hit-to-Lead journey of our clients. They offer innovative solutions to medicinal chemistry, synthetic chemistry, ADME-tox, integrated drug discovery, route-scouting and process research, GMP production. Thanks to our strategic alliance with Symeres, we offer our client also the possibility to screen the Symegold collection of approximatively 75.000 lead-like compounds synthesized at Symeres covering a lead-like diversity space not available in existing commercial libraries.

Through our relationship with Zobio, we offer biophysics and structural biology services to our clients, including protein engineering and production, fragment screening, structural biology with the combination of NMR spectroscopy and X-ray crystallography, biocore assays/screens, SPR assays.
Through LeadXPro, our clients have access to integral membrane protein structure and biophysics capabilities, such as protein design and generation, X-ray crystallography, cryo-electron microscopy, binding studies, Creoptix biophysical assays.

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