Hit & Lead Discovery
Hit and lead discovery are critical stages in the progression from target biology to high-quality chemical starting points for medicinal chemistry. At Axxam, we integrate experimental high-throughput screening (HTS) with virtual screening strategies to efficiently identify high-quality hit compounds.
Our approach integrates multidisciplinary expertise in biology, chemistry, engineering, and data analysis to ensure assay performance, data quality, and decision making are aligned from the outset.
By combining sensitive and robust assays with advanced screening technologies and in silico selection, we maximize the probability of identifying biologically relevant and chemically tractable hit compounds.
Hit selection is followed by structured hit-to-lead campaigns, supported by iterative testing, SAR development, and profiling in secondary and orthogonal assays. This integrated workflow improves compound quality, accelerates lead generation, and contributes to the overall de-risking of discovery programs.