Human-Relevant In Vitro Assays for Drug Discovery
Biochemical Assays
Enzymatic, binding, and biophysical assays supporting hit identification and validation.
Cell-based Assays
Cell-based assays to screen targets, pathways, and disease-relevant responses.
iPSC Platform
Model human disease biology using iPSC-derived cells for translational drug discovery.
Organellar Electrophysiology
Study lysosomal, mitochondrial, and nuclear ion channels for drug discovery.
High Content Assays
Image-based assays to capture complex cellular phenotypes and responses.
Optogenetics
Enable biologically relevant drug screening through optogenetics-based HTS assays.
Bitter Taste Receptor
Predict bitterness and off-tastes through human taste receptor assays.
In vitro assays are a key element of drug discovery, enabling controlled investigation of biological mechanisms and reliable assessment of compound activity, potency, selectivity, and safety.
At Axxam, we develop robust and innovative in vitro assay platforms to support informed decision making and to de-risk drug discovery programs from early target validation through lead optimization.
Our portfolio includes both cell-free (biochemical assays) and cell-based assays, providing complementary approaches for screening. We also use induced pluripotent stem cell (iPSC) platforms to generate physiologically relevant human cellular models for disease research and compound profiling.
In line with New Approach Methodologies (NAMs), our in vitro models deliver human-relevant and predictive data while supporting the reduction of animal testing. These approaches enable early identification of liabilities and improve translational confidence.
Our technology platforms include high-content imaging, electrophysiology, and optogenetics, enabling precise interrogation of complex cellular processes, including ion channels and transporters at the organelle level. Each assay type is designed to address specific stages of the drug discovery workflow, from target validation and primary screening to hit confirmation, lead optimization, and safety assessment, with applications also extending to agrochemicals, flavors, and fragrances.