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Drug Discovery Collaboration between Grünenthal and Axxam

Axxam SpA expands to U.S., opens office in Cambridge, Mass. Grünenthal capitalizes on Axxam’s drug discovery platform and expertise to identify small molecule lead structures for its early pipeline in pain and inflammation Aachen, Germany and Milano, Italy, March 3, 2016: Grünenthal and Axxam announced today that they have entered into an integrated collaboration. The objective is to discover novel small molecule lead structures for the development of pain and inflammation therapeutics by combining Axxam’s drug discovery platform with Grünenthal’s expertise on emerging and innovative biological pathways and targets. Open PDF Document

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Axxam and the NEOMED Institute to Collaborate on the Discovery and Development of a Novel Drug to Treat Metabolic Diseases

Axxam and the NEOMED Institute to Collaborate on the Discovery and Development of a Novel Drug to Treat Metabolic Diseases Montreal (Canada) and Milan (Italy) – February 18, 2016 – Axxam SpA, a leading discovery company with expertise in target biology and a broad range of early phase discovery solutions and NEOMED Institute, a public-private organization dedicated to drug discovery and the development of therapeutics up to human proof of concept, announced today that they have entered into a strategic drug discovery partnership. The aim of the collaboration is to identify and develop novel small molecule agonists of FFA4 (also known as GPR120) linked to a range of metabolic and inflammatory diseases. Several preclinical studies and human genetics data support the development of a GPR120 agonist as a highly differentiated treatment of diabetes with potential to impact a number of parameters, including protection of the pancreatic β-cells. Open PDF Document

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Axxam and the Neurodegeneration Consortium at The University of Texas MD Anderson Cancer Center collaborate on a novel approach to Alzheimer’s disease research

Axxam and the Neurodegeneration Consortium at The University of Texas MD Anderson Cancer Center collaborate on a novel approach to Alzheimer’s disease research Axxam SpA (Milan/Italy) announced today that it has entered into a research collaboration with the Neurodegeneration Consortium (NDC) at The University of Texas MD Anderson Cancer Center (MD Anderson). The aim of the collaboration is to identify and develop novel small molecule modulators of an undisclosed G-protein coupled receptor linked to Alzheimer’s disease. Open Pdf Document

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Axxam executes agreement with NYU Langone Medical Center for the provision of drug discovery services

Axxam executes agreement with NYU Langone Medical Center for the provision of drug discovery services October 14th, 2015 – Axxam SpA (Milan/Italy), a leading provider of discovery services has entered into a multi-year agreement with the Office of Therapeutics Alliances (OTA) of NYU Langone Medical Center (New York, US) to provide drug discovery expertise to advance their innovative pipeline of therapeutic programs. OTA is a drug discovery accelerator that provides resources to NYU Langone scientists to help translate their laboratory research into therapeutic discovery and a formal path towards the development of novel, FDA-approved drugs. Open Pdf Document

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Axxam SpA enters into a collaboration agreement with Bayer HealthCare for the provision of Drug Discovery Services

Axxam SpA enters into a collaboration agreement with Bayer HealthCare for the provision of Drug Discovery Services July 21st, 2015 – Axxam SpA (Milan/Italy), a leading provider of discovery services has entered into a multi-year collaboration agreement with Bayer HealthCare (Bayer), a global pharmaceutical company. The aim of this collaboration is to provide high level services to support Bayer’s strong commitment to discover new therapies for diseases with high unmet medical need. Open Pdf Document

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Axxam enters into a research collaboration with The University of Texas MD Anderson Cancer Center for Assay Development and High Throughput Screening of selected targets in oncology

Axxam enters into a research collaboration with The University of Texas MD Anderson Cancer Center for Assay Development and High Throughput Screening of selected targets in oncology June 18th, 2015 – Axxam SpA (Milan/Italy), a leading provider of discovery services, has entered into a multi-year collaboration with the Institute for Applied Cancer Science (IACS) at The University of Texas MD Anderson Cancer Center (MD Anderson).  The aim of the collaboration is to identify lead chemical matters against novel oncology targets provided by MD Anderson. The collaboration leverages Axxam’s expertise in assay development, Axxam’s fully automated screening platforms and access to Axxam’s novel compound collection AxxDiv2.0. The collaboration builds on a strong working relationship between Axxam and MD Anderson. Open PDF document

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Axxam announces the appointment of Dr. Russell Thomas as Director of Discovery Research

Axxam announces the appointment of Dr. Russell Thomas as Director of Discovery Research May 4th, 2015 – Axxam SpA (Milan/Italy), a privately owned contract research and discovery company, announced today that Dr. Russell Thomas has joined the company as Director of Discovery Research. Russell brings to Axxam considerable industry experience that spans from target discovery to clinical proof of concept at Siena Biotech, Proteros, Evotec and GlaxoWellcome. Russell is joining Axxam from Siena Biotech, where he was initially head of Medicinal Chemistry, before becoming Director of Project Operations and External Alliances and more recently General Manager. In these various roles Russell guided a range of neuroscience and oncology projects from initial hit validation and subsequent optimization, leading to a number of preclinical and clinical candidates. He is one of the inventors of selisistat, which is currently progressing through clinical trials as a potential disease modifying approach to Huntington’s disease. During his time at Proteros, in the role of Vice President of Lead Discovery, Russell had strategic responsibility for all existing and potential new collaborations with pharmaceutical and biotech partners and played a key role in the start-up of Rodin Therapeutics with Atlas Venture. At Evotec, as a Department Head in Medicinal Chemistry, Russell was responsible for guiding a range of discovery alliances with international pharmaceutical and biotech companies. These alliances led to the delivery of a number of preclinical and clinical candidates. In the seven years that Russell spent at Glaxo, subseqently GlaxoWellcome, he worked as a senior medicinal chemist, mainly in the field of antibacterials. Originally from Swansea in Wales, he obtained a Ph.D in synthetic organic chemistry in the group of Prof. Stan Roberts at Exeter University, after graduating in Chemistry from the University of Kent. Open PDF document

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Aptuit LLC and Axxam SpA announce Strategic Alliance for Integrated Drug Discovery Services.

Aptuit LLC and Axxam SpA announce Strategic Alliance for Integrated Drug Discovery Services. Commence major integrated discovery program for large Pharma sponsor Greenwich, CT and Milan (Italy) – April 14, 2015 – Aptuit LLC, a premier global drug discovery and development CRO and Axxam SpA, a leading discovery company with expertise in target biology and a broad range of early phase discovery solutions, announced a strategic alliance to provide comprehensive and integrated services from gene to high quality candidates and beyond. This partnership will allow the companies to offer the best-in-class fully integrated drug discovery and development services, supported by a culture of scientific excellence and innovation. Aptuit and Axxam are also delighted to announce that the partnership has already resulted in the commencement of the first significant joint integrated project with a large pharma sponsor. Open Pdf Document

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ALZHEIMER’S DRUG DISCOVERY FOUNDATION AND AXXAM CONTINUE THEIR SUCCESSFUL COLLABORATION TO DEVELOP NOVEL THERAPEUTICS FOR ALZHEIMER’S DISEASE

ALZHEIMER’S DRUG DISCOVERY FOUNDATION AND AXXAM CONTINUE THEIR SUCCESSFUL COLLABORATION TO DEVELOP NOVEL THERAPEUTICS FOR ALZHEIMER’S DISEASE   New York (USA) / Milan (Italy), 18th December 2014 –  The Alzheimer’s Drug Discovery Foundation (ADDF) and Axxam SpA (Axxam) announced today that ADDF has awarded a follow-on grant to Axxam to further develop small molecule drugs to treat Alzheimer’s disease by targeting inflammation. This grant follows two previous awards by ADDF to Axxam in 2011 and 2013.   The award will continue to fund a drug discovery project to identify compounds that selectively block the purinergic receptor, P2X7, which is involved in inflammation in the brain.  Research activities  under the previous grants have identified a new class of promising P2X7 selective antagonists that are currently under full expansion as well as lead compounds suitable for in vivo assessment in pharmacological models.   “Compounds that potently and selectively block P2X7 may treat brain inflammation and can potentially be useful in the treatment of Alzheimer’s disease and other neurodegenerative diseases,” said Howard Fillit, MD, Founding Executive Director and Chief Science Officer, ADDF.  “P2X7 is an unexplored target for this indication and we are excited to fund the program and investigate its therapeutic potential.”   “We are very pleased to obtain continuing support from the ADDF with this peer-reviewed grant, which recognizes the quality of our research capabilities in the challenging field of neuroinflammation and our ability to deliver what was promised,” said Stefan Lohmer, co-founder and CEO of Axxam.  “We are looking forward to continuing to work with the ADDF team and further move our Alzheimer’s disease program forward.”   Open PDF Document

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Axxam and F.Hoffman La Roche Ltd enter into research collaboration

Axxam and F.Hoffman La Roche Ltd enter into research collaboration Axxam SpA enters into research collaboration with F.Hoffmann – La Roche Ltd. for assay development and screening of selected drug targets Milan (Italy), November 19th, 2014 – Axxam SpA (Milan/Italy), a leading provider of discovery services has entered a collaboration with F. Hoffmann – La Roche Ltd to discover new small molecules targeting various targets across multiple disease areas. The collaboration will speed up the development of small molecule drugs by accessing Axxam’s specific target expertise and advanced screening technologies. The  research collaboration  includes  assay development, adaptation to fully automated screening stations and HTS using  the compound collection of F. Hoffmann – La Roche Ltd. Identified Hits will be characterized and validated with mode of action studies and selectivity screens  using  Axxam`s proprietary cell lines. The activities will be carried out both at the Axxam site in Milan, as well as at Hit Discovery Constance (HDC) GmbH in Constance/Germany, a new joint venture organisation between Axxam (Milan/Italy), Lead Discovery Center (Dortmund/Germany) and Centre for Drug Design and Discovery (CD3, KULeuven, Leuven/Belgium). Combined with HDC’s already established HTS services and compound storage facilities, Axxam represents one of the largest screening hubs worldwide. Dr. Doris Hafenbradl, VP Discovery Services at Axxam and Managing Director at HDC commented: “The collaboration with F.Hoffmann – La Roche is a further demonstration that our key expertise in assay development and  HTS  is well recognized within the pharmaceutical industry. Our continuous investments in enabling screening technologies, combined with our science-driven attitude is absolutely crucial to generate and deliver excellent data quality. We are very pleased  that F.Hoffmann – La Roche has selected us as a partner and we  are looking forward to collaborate intensively and successfully with our colleagues  at  F.Hoffmann – La Roche.” Open PDF document

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