About the Webinar:

Odorant and taste receptors together with their downstream signalling molecules have been detected in many tissues outside the olfactory epithelium or tongue, respectively. They frequently cluster in specialized chemoreceptor cells sparsely scattered along the epithelial lining of the airways and gastrointestinal tract.

By detecting irritants, pathogen-derived signals or nutrients these cells participate in a variety of nervous, endocrine or immune circuits with potential relevance for therapeutic intervention.

In addition, numerous studies have reported expression of taste or olfactory receptors in non-sensory cell types and claimed their contribution to regulate cell-specific functions. Finally, rare reports demonstrate the detection of chemosensing receptors as a result of aberrant epi- or genetic regulation in cancerous cells. As cancer specific antigens such receptors might bear potential as targets for immunotherapy.

In our webinar, we will provide selected cases for ectopic olfactory or taste receptors as potential drug targets together with AXXSense’s receptor platform for ligand discovery and characterization.        

In this webinar you will learn about:

• The roles of olfactory and taste receptors in tissues other than nose and tongue.
• Ectopic receptors as potential therapeutic targets.
• Axxam’s experimental platform for ligand discovery and pharmacological characterization for olfactory and taste receptors.

Keywords:

Olfactory receptor; taste receptor; ectopic receptor; functional expression; cell-based assay; compound library; high-throughput screening; drug target; chemosensing.

Speakers:

• Jörg Hüser, CSO – Axxam

• Marcel Winnig, Scientific Officer and Team Leader of AXXSense – Axxam