Axxam Collections
At Axxam, we provide an extensive selection of high-quality compound collections to accelerate your drug discovery projects. Our libraries, containing approximatively 450.000 small molecules, feature both universal collections, designed for broad unbiased chemical diversity, and focused collections, tailored to specific discovery needs.
Our libraries are assembled by incorporating compounds with structural and molecular properties suitable for the identification of tractable hits. They are meticulously selected by our chemists avoiding unwanted reactive chemical groups, frequent hitters, toxicophores, aggregators and other undesired chemical moieties.
Universal compound collections: AXXDiversity and Symegold
AXXDiversity and Symegold are complementary, high-quality compound collections specifically curated for screening purposes, with no overlap between the two. AXXDiversity consists of diverse, commercially sourced compounds carefully selected by our MedChem experts, while Symegold provides exclusive access to highly unique, non-commercial scaffolds. Both libraries are designed to offer flexibility and high impact for high-throughput screening projects.
The AXXDiversity library consists of around 350.000 chosen small molecules whose selection is built on our broad screening expertise, with a constant and significant input from our team of medicinal and computational chemists.
The compound selection is driven by quality and structural diversity from trusted commercial sources. The chemical space is actively nurtured and fueled to ensure it constantly evolves and responds to the shifting needs of the scientific community.
The AXXDiversity is available for screenings at Axxam, where a variety of assays and technologies are available, or as “screening ready plates” in 384- or 1536-well format for client’s in-house activities.
The collection consists of five independent screening sets, with no overlap, accessible separately or in combination according to your project’s needs.
Discovery set
- Around 180.000 molecules
- Mean of 15 analogues per chemotype
- Provides structure–activity relationship (SAR) information
ExplorerPLUS set
- Approximately 98.000 molecules
- High coverage of structural diversity (enriched unique scaffolds)
- Ideal for novel peripheral and central targets
ExplorerFAST set
- Around 24.000 molecules
- High chemical tractability, for a fast hit expansion
- sp3-rich non-flat screening compounds with high chemical diversity
New expansion: ExplorerFASTER set
- Around 1.000 proprietary triazole-enriched compounds
- High chemical tractability for an accelerated hit expansion (one step synthesis)
- 95% of powders already available at Axxam
ExplorerCNS set
- Around 35.000 singletons
- Optimized MPO for a higher probability of blood-brain barrier and cellular permeability
- Specifically biased towards CNS, pain and intracellular targets
Probe set
- Approximately 12.000 decorated fragment-like compounds
- Low molecular weight
- For an easy exploration of ligand-target interactions
The Symegold library is accessible for screening at our facility thanks to the strategic alliance with Symeres, a leading contract research organization offering innovative medicinal, synthetic and development chemistry, as well as ADME-Tox services.
Axxam focused libraries
Axxam’s focused libraries are expertly curated to address specific biological targets, interaction mechanisms or defined chemical space. These collections include NatPure, one of the largest natural compound libraries globally; AXXRNABind, designed for RNA interactions; AXXCovalent, featuring covalent molecules targeting reactive residues such as cysteine, serine, and histidine; AXXPPI, tailored for protein-protein interactions using machine learning algorithms; and Symecycle, a collection of macrocycles, offering a distinct edge in targeting challenging drug discovery projects. Each focused library is crafted to enhance screening efficiency and drug discovery outcomes.
The NatPure library is the largest pure natural product collection available globally, featuring around 15.000 compounds derived from plant and microbial sources, making it an exceptional resource for screening purposes.
Approximately 30% of the compounds are novel and unpublished, ensuring high chemical diversity, with around 4.900 distinct chemical clusters.
- Proprietary compound collection
- Solids available for all the compounds
- Comprehensive analytical characterization
AXXRNABind is a small molecule compound collection specifically designed to bind RNA. This collection is suitable to initiate discovery programs aimed at finding RNA splicing modulators and RNA-protein interaction modulators.
- Around 2.000 drug-like and lead-like compounds
- High novelty & chemical diversity
- Optimal starting point for MedChem programs
To leverage the advantages of covalent binding, Axxam has developed a focused library of 9.000 compounds, each carefully designed to optimize both covalent and non-covalent interactions.
This library has been rigorously curated to meet high standards in terms of chemical properties and diversity, with compounds synthesized within the last five years and each maintaining purity levels above 90%.
- More than 50 different warheads
- High structural seeker diversity for target selectivity
- 62% biast towards Cys, Ser, and His residues, the remaining 38% employs a non-specific targeting approach Synthesized in the last 5 years
Our Protein-Protein Interaction (PPI) small collection is specifically curated to facilitate the exploration of critical biological pathways.
This diverse set of compounds is designed at Axxam using generative Machine Learning algorithms trained with PPI physico-chemical properties and retailored to ensure positioning within a more drug-like chemical space. It offers a valuable resource for researchers aiming to understand and manipulate PPI networks in drug discovery.
- ~ 1.000 proprietary compounds, expected to reach 6.000 in 2026
- Specifically biased for Protein-Protein Interactions
- Solids available for all the compounds
Symecycle is a subset of 1.900 macrocycles meticulously designed and synthesized at Symeres labs.
Accessible as part of the Symegold collection or as a separate subset, these compounds strike an excellent balance between complexity and druglikeness, with molecular weights ranging from 370 to 640 Da and cLogP values between -2.5 and 5.2. They offer high novelty, as they are not commercially available, and a rapid hit expansion thanks to the availability of building blocks and reagents at Symeres labs.
- ~1.900 proprietary macrocycles (expected to reach 2.500 by the end of 2024)
- Accessible as part of the Symegold collection or as a separate subset
- Good balance between complexity and druglikeness
- Building blocks and reagents available at Symeres for rapid expansion of hits
