Webinar
Neurodegeneration at the Cellular Level: Organelles in the Spotlight
Webinar held in collaboration with FUJIFILM Cellular Dynamics
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About this webinar:
Organelles are specialized structures within cells. They play a crucial role in maintaining homeostasis by regulating essential cellular processes such as energy production, protein synthesis, and waste removal. Dysfunction of these organelles can disrupt normal cellular functions, contributing to the development and progression of various diseases, including neurodegenerative disorders like Parkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS). For example, impaired autophagic clearance leads to the accumulation of toxic proteins and damaged organelles, while mitochondrial dysfunction exacerbates energy deficits and oxidative stress.
Developing cell-based assays with human iPSC-derived cell types, that can accurately mimic such organellar alterations, could offer valuable insights about disease mechanisms. It can also offers opportunities for the creation of novel and effective therapeutic treatments.
In this webinar you will learn about:
- The range of cutting-edge services and expertise offered by Axxam for early-stage drug discovery projects.
- The utilization of iCell® products from FUJIFILM Cellular Dynamics to study neurodegeneration.
- How human iPSC-derived neurons can enhance current in vitro models of disease.
- The development of high-throughput screening (HTS)-compatible assays for studying neurodegeneration, organelle function, and neurotoxicity, with specific focus on high-content imaging and electrophysiological analysis of isolated organelles.
Keywords:
iPSC-derived neurons; iPSC-derived Microglia; Neurodegenerative diseases; Amyotrophic Lateral Sclerosis (ALS); Parkinson’s Disease (PD); High-throughput compatible functional assays; High content imaging assays; Organellar analysis; Lysosomes; Mitochondria; Electrophysiology; Organellar Patch Clamp; Drug Discovery.
Speakers:
Silvia Cainarca – Scientific Officer, Axxam
Scott Schachtele – Product Manager, FUJIFILM Cellular Dynamics
Silvia Cainarca has more than 20 years of experience in the drug discovery field, and a strong background in cellular and molecular biology. Her main expertise includes the development of functional cell-based assays, also with relevant cell types, for hit-to-lead programs, coordination of assay development and functional and epigenetic screening with iPS-derived cells. She has been project leader for grants financed by the European Community and by national and international funding, as well as a Principal Investigator in important collaborations with international clients and partners, in the field of iPS-derived cells. She has been in charge of the iPS Unit at Axxam for 8 years before passing to her current role of Scientific Officer with a specific focus on iPS strategies.
Scott Schachtele is the Product Manager for the Neural Portfolio at FUJIFILM Cellular Dynamics. He works closely with research teams at FUJIFILM Cellular Dynamics to develop and deliver iPSC-derived neural cells for use in drug discovery and preclinical research. Scott received his Ph.D. in Neuroscience from the University of Iowa and completed his postdoctoral training in Neuroimmune Pharmacology at the University of Minnesota.