AXXAM

Electrophysiology

Your channel, our solution

Are you working with electrogenic proteins? Do you need support studying ion channel, transporter and exchanger biology? Our team of skilled electrophysiologists have at their disposal a panel of both manual and automated patch-clamp devices allowing them to define the best strategy to assist your request. Our platforms are used during the assay development phase to pharmacologically and biophysically validate “in house generated” or transferred cell lines. Then, using the suitable tools, we design fine-tuned experimental conditions to perform small and medium-scale compound testing and primary screenings, as well as hit validation experiments and mode of action studies on ligand- and voltage-gated ion channels using the proper configuration (cell attached, whole-cell, inside-out or outside-out).

Discover our patch clamp platforms

  • Whole cell, inside- and outside-out configurations
  • Cellular and organellar electrophysiology
  • Low throughput compound profiling & mode-of-action studies
  • Optogenetics
  • iPSC-derived cell electrophysiology
  • Fast internal (Port-a-Patch) and external solution exchange
  • Medium-high throughput screening for hit discovery, hit confirmation and SAR campaign
  • On off-the-shelf assays or on adapted clients’ assays
  • Preliminary cardiac safety profiling
  • Fast internal solution exchange
  • Suitable for iPSC-derived cell electrophysiology
  • Implemented for Genedata analysis settings

  • Fully automated high throughput screening for hit discovery, hit confirmation and SAR campaign
  • On tailored-made assays or on clients’ assays
  • Suitable for clone selection during cell line generation
  • Fast internal solution exchange
  • iPSC-derived cell electrophysiology
  • Implemented for Genedata analysis settings

Off-the-shelf assays

Axxam has already validated several assays that can immediately been used for services and additional assays can be adapt upon client’s request. 

Interested in going deeper into the cell?

In the last few years, we have a huge expertise on organellar electrophysiology by manual or semi-automated mode
allowing the study of ion channels localized on the membrane of nuclei (NucleoPatch), lysosomes (LysoPatch) and mitochondria (MitoPatch).

Related Content

Please find below a selection of our scientific publications and posters:
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